Quantifying the effects of CO2 on the resting BOLD signal

نویسندگان

  • T. Peng
  • R. Niazy
  • R. Wise
چکیده

Introduction Low-frequency fluctuations in the blood oxygen level-dependent (BOLD) signal are an important component of ‘physiological noise’ in functional MRI signals. Identification and characterization of these sources is extremely important in order to develop noise reduction strategies and hence obtain more accurate activation maps. Spontaneous low frequency fluctuations in arterial carbon dioxide (CO2) have previously been identified as an important factor in the resting BOLD signal through the use of linear regression analysis. However, it is well known that there is a strongly frequency dependent relationship between CO2 and CBF, in which CO2 effects are concentrated in the low frequency range 0-0.05Hz. We therefore hypothesize that the effects of CO2 on the resting state BOLD signal are also restricted within low frequencies and investigate the frequency-dependent effects of CO2 on the resting state BOLD signal by using wavelet cross-correlation analysis.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Agreement and repeatability of vascular reactivity estimates based on a breath-hold task and a resting state scan

FMRI BOLD responses to changes in neural activity are influenced by the reactivity of the vasculature. By complementing a task-related BOLD acquisition with a vascular reactivity measure obtained through breath-holding or hypercapnia, this unwanted variance can be statistically reduced in the BOLD responses of interest. Recently, it has been suggested that vascular reactivity can also be estima...

متن کامل

Relationship between Respiratory Variations and End-tidal Co2 in Bold Fmri Physiological Noise

Introduction Physiological processes introduce noise into the BOLD fMRI time series, thereby interfering with studies of neural activation and connectivity. One major source of physiological noise can be traced to subtle variations in respiration depth and rate[1]. It has been shown that one can model and reduce such effects by (1) computing a breath-to-breath measure of respiratory variation (...

متن کامل

Effect of Phase-Encoding Reduction on Geometric Distortion and BOLD Signal Changes in fMRI

Introduction Echo-planar imaging (EPI) is a group of fast data acquisition methods commonly used in fMRI studies. It acquires multiple image lines in k-space after a single excitation, which leads to a very short scan time. A well-known problem with EPI is that it is more sensitive to distortions due to the used encoding scheme. Source of distortion is inhomogeneity in the static B0 field that ...

متن کامل

Low-frequency respiration related signals in resting state fMRI: a comparison of end-tidal CO2 and respiration volume per time

Introduction Functional connectivity analysis has been used to map several consistent resting state networks by exploiting coherent low-frequency fluctuations in the BOLD signal. The assumption in most of the fMRI literature is that these correlated fluctuations are neuronal in origin. Others sources of low-frequency fluctuations exist in fMRI data that are unrelated to neuronal activity. These...

متن کامل

Choosing the Distinguishing Frequency Feature of People Addicted to Heroin from Healthy while Resting

Addiction is a biological, psychological, and social disease. Several factors are involved in etiology, substance abuse, and addiction which interact with each other and lead to the beginning of drug use and then addiction. Heroin is an addictive drug that, by acting on the central nervous system, reduces the density of neurons in the brain and interferes with decision making. This paper examin...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2008